Gap and Low-Resistance Junctions between Cells in Culture
نویسندگان
چکیده
منابع مشابه
Gap and low-resistance junctions between cells in culture.
In vitro cultured cells are connected by different membrane junctions which may serve as a matrix for the monolayer, but which may also enable intercellu lar communication. Some of these intercellular infor mation exchanges may be detected by ionic coupling between the cells through so-called “low-resistance junctions” . Gilula and cow orkers1, for instance, have shown that metabolic cooperat...
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Electrophysiological studies of low-resistance junctions between Novikoff hepatoma cells grown in suspension cultures were carried out and correlated with gap-junctional areas per inferface determined by freeze-fracture. The mean coupling coefficient between isolated cell pairs was 0.773 +/- 0.025 (SEM) in 67G medium and 0.653 +/- 0.028 in M67 medium; the respective means for the central pairs ...
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Electrical coupling, which reveals the presence of specialized low-resistance intercellular junctions, has now been found in four types of tumors, Sarcoma 180, Novikoff hepatoma, and Morris hepatomas 3924-A and 7777. Coupled cancer cells were distinguished from coupled normal cells by intracellular marking techniques. Although the evidence suggests that coupling may be extensive in some cases, ...
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Although circumstantial evidence has suggested that gap junctions mediate intercellular electrotonic coupling, it has not been possible in most tissues to exclude the involvement of other, coexisting cell junctions. We have made an electron microscopic study of replicas of frozen-fractured BHK21 cells (from tissue culture) and of brown fat cells of newborn mice. Both of these cell types are kno...
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In the outer plexiform layer of the retina the synaptic endings of cone cells make specialized junctions with each other and with the endings of rod cells. The ultrastructure of these interreceptor junctions is described in retinas of monkeys, rabbits, and turtles, in thin sections of embedded specimens and by the freeze-fracturing technique. Cone-to-rod junctions are ribbon-like areas of close...
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ژورنال
عنوان ژورنال: Zeitschrift für Naturforschung C
سال: 1973
ISSN: 1865-7125,0939-5075
DOI: 10.1515/znc-1973-9-1019